More Publications

74.  Analysis of small molecule interactions using Biacore S51 technology,  Myszka DG (2004) Anal. Biochem. 329: 316-323.


73. Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology,  Cannon MJ, Papalia GA, Navratilova I, Fisher RJ, Roberts LR, Worthy KM, Stephen AG, Marchesini GR, Collins EJ, Casper D, Qiu H, Satpaev D, Liparoto SF, Rice DA, Gorshkova II, Darling RJ, Bennett DB, Sekar M, Hommema E, Liang AM, Day ES, Inman J, Karlicek SM, Ullrich SJ, Hodges D, Chu T, Sullivan E, Simpson J, Rafique A, Luginbühl B, Nyholm Westin S, Bynum M, Cachia P, Li Y-J, Kao D & Myszka DG (2004)  Anal. Biochem. 330: 98-113.


72. The ABRF-MIRG'02 Study: Assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction,  Myszka DG, Abdiche Y, Arisaka F, Byron O, Eisenstein E, Hensley P, Thomson J, Lombardo C, Schwarz F, Stafford W & Doyle M (2003). J. Biomolec. Techniq. 14: 247-269.


71. SPR's high impact on drug discovery: resolution, throughput, and versatility, Myszka DG & Rich RL (2003)  Drug Discovery World Spring: 1-5.


70. A survey of the year 2002 commercial optical biosensor literature, Rich RL & Myszka DG (2003) J. Mol. Recog. 16: 351-82.


69. Analyzing the binding of low molecular mass compounds using Biacore S51, Cannon MJ & Myszka DG (2003) Recent Res. Devel. Biophys. Biochem. 3: 333-344.


68. Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac,  Huang Y, Rich RL, Myszka DG & Wu H (2003)  J. Biol. Chem. 278: 49517-49522.

67. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor, Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD & Yuan J (2003) Cell 114: 99-111.


66. Spying on HIV with SPR biosensors, Rich RL & Myszka DG (2003) Trends Microbiol. 11: 124-133.


65. Capture and reconstitution of G protein-coupled receptors on a biosensor surface, Stenlund P, Babcock GJ, Sodroski J & Myszka DG (2003) Anal. Biochem. 316: 243-250.


64. Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate sitespecific DNA binding, Evans-Galea MV, Blankman E, Myszka DG, Bird AJ, Eide DJ & Winge DR (2003) Biochemistry 42: 1053-1061.


63. Characterizing a drug’s primary binding site on albumin, Day YSN & Myszka DG (2003) J. Pharm. Sci. 92: 333-343.


62. An RNA complex of the HIV-1 A-loop and tRNA(Lys,3) is stabilized by nucleoside modifications, Bajji AC, Sundaram M, Myszka DG, & Davis DR (2002) J. Am. Chem. Soc. 124:14302- 14303.


61. Mutational analyses of the p35/caspase interaction. A bowstring kinetic model of caspase inhibition by P35, Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, & Wu H (2003) J. Biol. Chem. 278: 5455-5461.


60. Survey of the year 2001 commercial optical biosensor literature, Rich RL & Myszka DG (2002) J. Mol. Recog. 15: 325-376.


59. Surface plasmon resonance characterization of drug-liposome interactions, Baird CL, Courtenay ES & Myszka DG (2002) Anal. Biochem. 310: 93-99.


58. Structure-activity analysis of the purine-binding site of human liver glycogen phosphorylase, Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YSN, Myszka DG & Rath VL (2002) Chem. Biol. 9: 8562-8567.


57. Kinetic analysis of estrogen receptor/ligand interactions, Rich RL, Hoth LR, Geoghegan KF, Brown TA, LeMotte PK, Simons SP, Hensley P & Myszka DG (2002)  Proc. Natl Acad. Sci. USA 99: 8562-8567.


56. Complex role of the β2β3 loop in the interaction of U1A with U1 hairpin II RNA, Katsamba PS, Bayramyan M, Haworth IS, Myszka DG & Laird-Offringa IA (2002) J. Biol. Chem. 277: 33267-33274.


55. Structure and functional interactions of the Tsg101 UEV domain,  Pornillos O, Alam SL, Rich RL, Myszka DG, Davis DR & Sundquist WI (2002)  EMBO J. 21: 2397-2406.


54. Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding, Liparoto FS, Myszka DG, Wu Z, Goldstein B, Laue TM & Ciardelli TL (2002) Biochemistry 41: 2543-2551.


53. Direct comparison of equilibrium, thermodynamic, and kinetic rate constants determined by surface- and solution-based biophysical methods, Day YSN, Baird CL, Rich RL & Myszka DG (2002) Protein Science 11: 1017-1025.


52. Surface plasmon resonance biosensors, Homola J, Yee SS & Myszka DG (2002) Optical Biosensors: Present and Future (Ed. Frances Ligler) pp. 207-251.

51. Equilibrium and kinetic analyses of the interactions between vitamin B12 binding proteins and cobalamins by surface plasmon resonance, Cannon MJ, Myszka DG, Bagnato JD, Alpers DH, West FG & Grissom CB (2002) Anal Biochem. 305: 1-9.


50. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding, Garrus JE, von Schwedler UK, Pornillos OW, Morham SG, Zavitz KH, Wang HE, Wettstein DA, Stray KM, Côté M, Rich RL, Myszka DG & Sundquist WI (2001) Cell 107: 55-65.


49. Current and emerging optical biosensors, Baird CL & Myszka DG (2001) J. Mol. Recog. 14: 261-268.


48. Biochemical analyses of the interactions between human immunodeficiency virus type-1 Vpr and p6Gag, Jenkins Y, Pornillos O, Rich RL, Myszka DG, Sundquist WI & Malim MH (2001) J. Virology 75: 10537-10542.


47. High-resolution and high-throughput protocols for measuring drug/human serum albumin interactions using BIACORE, Rich RL, Day YSN, Morton TA & Myszka DG (2001) Anal. Biochem. 296: 197-207.


46. Survey of the year 2000 commercial optical biosensor literature, Rich RL & Myszka DG (2001) J. Mol. Recog. 14: 273-294.


45.  Recent developments in SPR biosensor technology: Application of BIACORE J, Rich RL & Myszka DG (2001)  Chemical Sensors (Chinese) 21: 14-23.


44. G-protein signaling through tubby proteins, Santagata S, Boggon TJ, Baird CL, Shan W-S, Gomez C, Myszka DG & Shapiro L (2001) Science 292: 2019-2021.


43. Covalent caspase inhibition revealed by the crystal structure of the caspase-8/p35 complex, Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG & Wu H (2001) Nature 410: 494-497.


42. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA, Katsamba PS, Myszka DG & Laird-Offringa IA (2001) J. Biol. Chem. 276: 21476-21481.


41. BIACORE J: a new platform for routine biosensor analysis, Rich RL & Myszka DG (2001) J. Mol. Recog. 14: 223-228.


40. Structural basis of caspase inhibition by XIAP: Differential roles of the linker versus the BIR domain, Huang Y, Park YC, Rich RL, Segal D, Myszka DG & Wu H (2001) Cell 104, 781-790.


39. Survey of the 1999 optical biosensor literature, Rich RL & Myszka DG (2000) J. Mol. Recog. 13: 388-407.


38. Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides, Mehrotra B, Myszka DG & Prestwich GD (2000) J. Biol. Chem. 39: 9679-9686.


37. Implementing surface plasmon resonance biosensors in drug discovery, Myszka DG & Rich RL (2000) Pharmaceutical Science & Technology Today 3: 310-317.


36. Energetics of the HIV gp120-CD4 binding reaction, Myszka DG, Sweet RW, Hensley P, Brigham-Burke M, Kwong, PD, Hendrickson WA, Wyatt R, Sodroski J & Doyle ML (2000) Proc. Natl. Acad. Sci. USA 97:9026-9031.


35. Evaluating the energetics of erythropoietin ligand binding to the homodimerized receptor extracellular domain, Hensley P, Doyle ML, Myszka DG, Woody RW, Brigham-Burke MR, Erickson-Miller CL, Griffin CA, Jones CS, McNulty DE, O'Brien SP, Amegadzie BY, MacKenzie L, Ryan MD & Young PR (2000) Methods Enzymol. 323: 177-207.


34.  Equilibrium, kinetic and thermodynamic analysis on BIACORE, Myszka DG (2000) Methods Enzymol. 323: 325-340.


33. Kinetic studies of the HIV TAR RNA kissing hairpin complex and its stabilization by 2-thiouridine modification, Nair TM, Myszka DG & Davis DR (2000)  Nucleic Acids Res. 28, 1935-1940.


32. HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA, Park S, Myszka DG, Yu M, Littler SJ & Laird-Offringa IA (2000) Mol. Cell Biol. 20: 4765-4772.


31. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction, Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou H-C, Myszka DG & Wu H (2000) Cell 101: 777-787.


30. Sorting needles form haystacks, Hensley P & Myszka DG (2000) Curr. Opin. Biotech. 11: 9-12.


29. Advances in surface plasmon resonance biosensor analysis, Rich RL & Myszka DG (2000) Curr. Opin. Biotech. 11: 54-61.


28. Survey of 1998 optical biosensor literature. Myszka DG (1999) J. Mol. Recog. 12: 390-408.


27. Analysis of fibril elongation using a surface plasmon resonance biosensor, Myszka DG, Wood S, & Biere AL (1999) Methods Enzymol. 309: 386-402.


26.  Improving biosensor analysis.  Myszka DG (1999) J. Mol. Recog. 12: 1-6.


25. Equilibrium analysis of high affinity interactions using BIACORE, Myszka DG, Jonsen MD, & Graves BJ (1998) Anal. Biochem. 265: 326-330.


24. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones, Stuart JK, Myszka DG, Joss L, Mitchell RS, McDonald SM, Takayama S, Xie Z, Reed JC & Ely KR (1998) J. Biol. Chem. 273: 22506-22514.


23. Interpreting kinetic rate constants from optical biosensor data recorded on a decaying surface, Joss L, Morton TA, Doyle ML & Myszka DG (1998) Anal. Biochem. 261: 203-210.


22. CLAMP: a biosensor kinetic data analysis program, Myszka DG & Morton TA (1998) TIBS 23: 149-150.


21. Extending the range of rate constants available from BIACORE: interpreting mass transport influenced binding data, Myszka DG, Xiaoyi H, Bembo, M, Morton TA & Goldstein (1998) Biophys. J. 75: 583-594.


20. Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors, Morton TA & Myszka DG (1998) Methods Enzymol. 295 268-294.


19. Molecular recognition in the HIV-1 capsid/cyclophilin A complex, Yoo S, Myszka DG, Yeh C, McMurray M, Hill CP,& Sundquist WI (1997) J. Mol. Biol. 269, 780-795.


18. Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors, Myszka DG (1997) Curr. Opin. Biotech. 8, 50-57.


17. Kinetic analysis of a protein antigenantibody interaction limited by mass transport on an optical biosensor, Myszka DG, Morton TA, Doyle M & Chaiken IM (1997) Biophsy. Chem. 64, 127-137.

16. Kinetic and structural analysis of CD4 mutant variants defective in HIV binding, Wu H, Myszka DG, Tendian SW, Brouillette CG, Sweet RW, Chaiken IM & Hendrickson WA (1996) Proc. Natl Acad. Sci. USA 93: 15030-15035.


15. Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface, Myszka DG, Arulanantham PR, Wu Z, Sana T & Ciardelli T (1996) Protein Science 5: 2468-2478.


14. Global analysis of a macromolecular interaction recorded on BIAcore, Roden LD & Myszka DG (1996) Biochem. Biophys. Res. Commun. 225: 1073-1077. 


13. Molecular interaction analysis in ligand design using kinetic and thermodynamic methods, Doyle M, Myszka DG & Chaiken IM (1996) J. Mol. Recog. 9: 65-74.


12. New opportunities for using immobilized ligands to characterize macromolecular recognition and design recognition molecules, Chaiken IM, Myszka DG & Morton TA (1996) Advances in Molecular and Cellular Biology, JAI Press. 15B: 551-566.


11. Storage stability of the solution formulation of sCD4 determined by DCS in comparison with two functional assays,  Brouillette CG, Tendian SW, Heard BC, Dunleavy D, Shorter AL, Myszka DG & Chaiken IM (1996)  J. Therm. Analysis. 47: 1597-1609.


10. The coiled coil stem loop miniprotein as a presentation scaffold. Miceli R, Myszka DG, Mao J, Sathe G & Chaiken, IM (1996) Drug Design and Discovery 13: 95-105.


9. Phage expression of a de novo designed coiled coil stem loop miniprotein scaffold for constrained peptide library display,  Miceli RM, Myszka DG, Peishoff CE & Chaiken IM (1996)  Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. Chapter 16, 172-185. (ACS).


8. Interdomain communication of T-cell CD4 studied by absorbance and fluorescence difference spectroscopy measurements of urea-induced unfolding, Tendian SW, Myszka DG, Sweet RW, Chaiken IM & Brouillette CG (1995) Biochemistry, 34: 6464-6474.


7.  Interpreting complex binding kinetics from optical biosensors: a comparison of linear analysis, the integrated rate equation and numerical integration,  Morton TA, Myszka DG & Chaiken IM (1995) Anal. Biochem., 227: 176-185.


6. Design and characterization of an intramolecular antiparallel coiled coil peptide, Myszka DG & Chaiken IM (1994) Biochemistry, 33: 2363-2372.


5. De novo design of a coiled-coil stem-loop peptide, Myszka DG & Chaiken IM (1994) Peptides - Chemistry, Structure and Biology, (R. Hodges ed.) ESCOM, Leiden, p. 1060-1062.


4. Controlled formation of model homo- and heterodimer coiled coil polypeptides, Graddis TJ, Myszka DG & Chaiken IM (1993) Biochemistry, 32: 12664-12671.


3. Identification of fatty acid-binding protein as a potential Warfarin receptor present in crude rat liver cytosol and microsomes by photoaffinity labeling, Myszka DG & Swenson RP (1991) J. Biol. Chem. 266: 20725-20731.


2. Synthesis of the photoaffinity probe 3-(pazidobenzyl)-4-hydroxycoumarin and identification of the dicoumarol binding site in rat liver NAD(P)H:quinone reductase, Myszka DG & Swenson RP (1991) J. Biol. Chem. 266: 4789-4797.


1. Synthesis of 3-(4-azido-5-iodosalicylamido)-4-hydroxycoumarin: photoaffinity labeling of rat liver dicoumarol-sensitive NAD(P)H:quinone reductase, Myszka DG & Swenson RP (1990) Biochem. Biophys. Res. Commun. 172: 415-422.